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Natrilix® is an antihypertensive and a diuretic medicine indicated for the management of high blood pressure (hypertension) and edema (fluid overload) associated with heart, liver, kidney or lung disease. The treatment with Natrilix® helps lower volume of fluid in the blood vessels and so reduces blood pressure. The medication is best suited for patients over 18 years of age.

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Natrilix® is manufactured by Serdia Pharmaceuticals Pvt. Ltd. The drug contains the active ingredient Indapamide, a sulfamyl diuretic with antihypertensive activity, derived from chlorosulphonamide. The medication is used to reduce high blood pressure and edema (swelling), caused by heart, liver, and kidney problems. It functions by removing extra water from the body and lowering blood pressure. Over time it also promotes blood vessels relaxation, improves blood flow and reduces chances of heart attacks and kidney disorders.


- management of mild to moderate hypertension;

- edema associated with congestive heart failure, liver, kidney or lung disease;

- management of nephrogenic diabetes insipidus (should not be confused with diabetes mellitus or sugar diabetes), followed by abnormal production of urine (polyuria) and constant thirst (polydipsia).

MOA (mechanism of action):

Indapamide, a thiazide-like diuretic, and antihypertensive agent, is rapidly and completely absorbed after oral administration. Like other thiazide-like diuretics, Indapamide inhibits reabsorption of sodium and chloride ions, as well as water, in the Henle loop and in the distal kidney tubules, which leads to their excretion from the body, thus reducing edema, caused by excess fluid trapped in body's tissues. Indapamide's antihypertensive action is exercised in diminished plasma osmolarity and fluid volume in the blood vessels, alongside with a decreased peripheral vascular resistance which promotes a lowering of high blood pressure in hypertensive patients. The drug also has the ability to inhibit calcium ions in smooth muscle cells, thereby causing arteriolar vasodilation in hypertensive patients.


The recommended dose is 2,5 mg per day, taken in the morning. The Natrilix® tablets should be swallowed whole with a glass of water.

Missing a dose

If you miss a dose of Natrilix® you should take it as soon as possible. If it is the time for the next dose, skip the missed dose and go back to your regular dosing schedule. Do not take a double dose to make up for a forgotten one. Do not exceed the doctor’s recommended dose.


If an overdose occurs and you are feeling unwell, you should seek emergency medical attention or contact your healthcare provider immediately. Do not exceed the doctor’s recommended dose.


Store at a room temperature below 25°C (77°F) away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the sight and reach of children.

Side effects

The most common side effects associated with Natrilix® are:

  • - swelling of the lips or tongue
  • - shortness of breath
  • - muscle cramps
  • - heart rhythm irregularities
  • - red raised skin rash
  • - vomiting
  • - red pinpoints on the skin (purpura)
  • - dizziness
  • - tiredness
  • - headache
  • - vertigo
  • - nausea
  • - dry mouth
  • - constipation

Side effects occurrence does not only depend on the medication you are taking, but also on your overall health and other factors.


Do not take Natrilix® if you are allergic to Indapamide, any other sulfonamide or to any of the other ingredients contained in this medicine.

Do not use the medication if you have severe kidney disease.

Do not take the Natrilix® tablets if you have a severe liver disease or suffer from a hepatic encephalopathy (liver problems which affect the central nervous system).

Do not use the drug if you have low potassium levels in your blood.

Do not consume alcohol while taking Natrilix® as it may decrease its antidiuretic effect.

Use with caution if you have diabetes, any heart rhythm problems or suffer from gout.

Do not take the tablets if you need to have a test to assess the functioning of your parathyroid gland.

Use Natrilix® with caution if you are an athlete as this medicine contains an active ingredient, which may give a positive reaction in doping tests.

Do not use the medicine in combination with lithium (used to treat depression) as it may increase levels of lithium in the blood, and NSAIDs, which may cause renal failure.

Do not combine the use of Natrilix® with ACTH and corticosteroids to avoid the risk of hypokalemia increase.

Do not take Natrilix® if you are pregnant or breastfeeding.

Do not use Natrilix® in patients under 18 years of age.

Q: What is Natrilix® used for?

A: Natrilix® is an antihypertensive and a diuretic medicine used in hypertension and edema, caused by heart, liver, kidney or lung disease.

Q: Can I drive while taking this medicine?

A: Natrilix® can make some people feel dizzy or tired, therefore you should make sure you know how your body reacts to the medication before driving or operating machinery.

Q: Is Natrilix® safe during pregnancy or while breastfeeding?

A: This medicine is not recommended during pregnancy. When a pregnancy is planned or confirmed, you should consult your doctor and switch to an alternative treatment. Breastfeeding while taking Natrilix® tablets is also not advisable as the active ingredient is excreted in milk.

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