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Tenvir-EM®

Description

Tenvir-EM® is anti-retroviral drug used in HIV-1-positive patients who weigh at least 35 kg. Tenvir-EM® is not able to completely cure HIV-1. It is normally used as part an of anti-retroviral therapy. Tenvir-EM® may successfully treat and control HIV-1 infection.

Other names for this medication:

Truvada, Tenof EM®, Tofocom®, Tentide EM®, Ricovir EM®

Active Ingredient:

Tenofovir Disoproxil, Emtricitabine

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Description

Tenvir-EM® is manufactured by Cipla. The raw materials are Emtricitabine (FTC), a nucleoside reverse transcriptase inhibitor and Tenofovir (TDF) is a nucleotide reverse transcriptase inhibitor.

Indications:

- human immunodeficiency virus 1 (HIV-1) infection in adults together with other anti-retrovirals;

- human immunodeficiency virus 1 (HIV-1) infection in treatment-experienced adolescents aged 12 to less than 18 years who weigh at least 35 kg together with other anti-retrovirals.

MOA (mechanism of action):

Tenofovir and Emtricitabine are known as NRTIs and they work by interfering with the normal working of an enzyme reverse transcriptase that is crucial for the HIV to reproduce itself. Tenvir-EM® reduces the viral load in blood, increases the count of CD4 (T) cells in blood which aids in warding off other infections. This strengthens the immune system and lowers the risk of death or infections that can happen when immune system is weak. Tenofovir and Emtricitabine are not active against HIV-2.

Dosage

The usual dose of Tenvir-EM® is one tablet once a day.

Do not change your dose or stop taking Tenvir-EM® without first talking with your healthcare provider.

Take Tenvir-EM® as directed by your doctor.

Take Tenvir-EM® at the same time each day.

Take Tenvir-EM® with or without food.

Do not run out of Tenvir-EM®. Refill the prescription or talk to your doctor before Tenvir-EM® is gone.

Some people who take Tenvir-EM® may experience:

- Kidney problems, including kidney failure.

- Lactic acidosis (a buildup of lactic acid in the blood). The symptoms are unexpected tiredness or weakness, nausea or vomiting, constant abdominal pain, pancreatitis. If any of these symptoms occur, seek emergency medical attention immediately.

- Serious liver problems: hepatomegaly, steatosis. The symptoms of liver problems: jaundice, dark “tea-colored” urine, light-colored bowel movements, loss of appetite for several days or longer, nausea. If you experience these symptoms, seek emergency medical attention immediately.

- Immune Reconstitution Syndrome – a condition when immune system may get stronger and starts fighting infections that have been hidden in the body for a long time.

Precautions:

HIV can be transmitted through sexual contact with infected partner, blood (e.g., sharing needles, handling blood instruments, receiving blood transfusions, blood products, or organ/tissue transplants that were infected with HIV), childbirth, toiletries (razors and toothbrushes). Therefore, both infected and non-infected individuals are advised to have any kind of sex using a latex or polyurethane condom, avoid sharing needles or other things like toothbrushes or razors. It is important to discuss with doctor the precautions needed to avoid infecting other people as well as take precautions not to get infected.

Tenvir-EM® is not approved to treat HBV. If you have HBV and stop taking Tenvir-EM®, your HBV may suddenly get worse. Do not stop taking Tenvir-EM® without first talking to your doctor, as your health must be monitored regularly.

Women who are HIV-positive must not breastfeed because HIV infection can be passed on to the baby in breast milk.

Missing a dose

If you miss a dose you should take it as soon as you remember about your missing. If it is the time for the next dose you should continue your regular dosing schedule. Do not take a double dose of Tenvir-EM® to compensate the missed dose.

Overdose

If an overdose occurs and you are not feeling well, stop taking the medication immediately. You should seek emergency medical attention or contact your healthcare provider immediately.

Storage

Store Tenvir-EM® tablets or oral powder at room temperature between 68-77 degrees F (20-25 degrees C). Keep Tenvir-EM® in the original container. Do not use Tenvir-EM® if the seal over the bottle opening is broken or missing. Keep the bottle tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common and uncommon side effects associated with Tenvir-EM® are:

  • diarrhea
  • nausea
  • tiredness
  • headache
  • dizziness
  • depression
  • problems sleeping
  • abnormal dreams
  • rash

Side effects occurrence does not only depend on the medication you are taking, but also on your overall health and other factors.

Contraindications

Tenvir-EM® is contraindicated in patients who are allergic to Emtricitabine, Tenofovir or any of the other ingredients of Tenvir-EM®.

Do not use Tenvir-EM® in patients under 12 years of age with weight less than 35 kg.

Do not let your Tenvir-EM® run out. Refill your tablets if therapy is continued.

Do not stop taking Tenvir-EM® suddenly and without first talking to the doctor.

Do not take Tenvir-EM® if you have liver problems, including HBV infection, kidney problems, bone problems, have any other medical conditions, including HIV infection, are pregnant or plan to have baby, are breastfeeding or plan to breastfeed.

Do not take Tenvir-EM® with other medicines that contain Tenofovir (Atripla®, Complera®, Stribildtm, Truvada), adefovir (Hepsera®), didanosine (Videx, Videx EC), atazanavir (Reyataz), lopinavir with ritonavir (Kaletra), darunavir (Prezista), ledipasvir with sofosbuvir (Harvoni®), sofosbuvir with velpatasvir (Epclusa®).

Alcoholism, hepatic disease, hepatotoxicity or lactic acidosis, obesity, organ transplantation are contraindications for using Tenvir-EM®.

Tenvir-EM® is contraindicated in patients with heart disease, high blood pressure, liver disease, a risk factor for heart disease such as smoking, diabetes, or high cholesterol, or if you have used any other HIV medication in the past.

Do not have any kind of sex without using a latex or polyurethane condom.

Do not share needles or other things like toothbrushes or razors.

Consult doctor first before taking Tenvir-EM® if you are pregnant or plan to become pregnant.

Women who are HIV-positive must not breastfeed because HIV infection can be passed on to the baby in breast milk.

Q: What is Tenvir-EM® used for?

A: Tenvir-EM® is an anti-retroviral drug used in HIV-1-positive patients who weigh at least 35 kg. Tenvir-EM® is not able to completely cure HIV-1. It is normally used as part an of anti-retroviral therapy. Tenvir-EM® may successfully treat and control HIV-1 infection.

Q: Can I have sex when taking Tenvir-EM®?

A: You should know neither Tenvir-EM® nor any other anti-retroviral medication can cure HIV. It is therefore important that you have safe sex and take other precautions to avoid passing HIV on to other people. Do not have any kind of sex without using a latex or polyurethane condom.

Q: Is Tenvir-EM® safe during pregnancy?

A: Consult doctor first before taking Tenvir-EM® if you are pregnant or plan to become pregnant.

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